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Team lands NIH funds to examine tuberculosis and metabolism

…ding to the World Health Organization. In 2013, an estimated 9 million people became ill with TB and 1.5 million died from the disease. The TBRU in which CSU is involved, “Metabolic Factors that Control the Spectrum of Human Tuberculosis,” is expected to receive up to $19.5 million over seven years. The unit will examine how the chronic bacterial infection changes metabolism and why altered metabolism increases TB disease susceptibility….

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CSU study offers new recommendations for TB vaccine testing in humans

…t of the vaccines out there use laboratory strains in testing. Ian has led the field to push for testing clinical strains.” The study, “The efficacy of the BCG vaccine against newly emerging clinical strains of Mycobacterium tuberculosis,” was published in September. Learn more about CSU’s tuberculosis research and the scientists looking for new ways to test for TB, new drugs to treat it, and vaccines to prevent tuberculosis before or…

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Immunology professor lands national honor for TB research

…rch Laboratories, which has grown to include more than 150 research personnel. It is located in one of the most secure laboratories of its kind in the world, where researchers can work with some of the most virulent types of tuberculosis. “With over 2 billion people infected with M. tuberculosis worldwide, the current and future potential impact of Dr. Orme’s work is truly impressive,” AAAS Fellow Jeffrey Wilusz, one of Orme’s fellow professors…

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Breakthrough imaging tool maps cells in 3-D at nanoscale

…-kind cellular imaging technology. Menoni devised and built the instrument with help from students and found a partner in CSU’s renowned Mycobacteria Research Laboratories, which seek new treatments for the global scourge of tuberculosis. The partners described the system in a paper published earlier this year in Nature Communications. Unprecedented detail Dean Crick, a professor who researches tuberculosis, collaborated with Menoni to refine…

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Students compete with research in health, medicine

…professor of mycobacterial pathology The infectious disease tuberculosis is a leading cause of death around the world. Joen aims to use small molecule compound adjuvants to overcome the antibiotic resistance of Mycobacterium tuberculosis. The approach could boost immunity and improve therapeutic strategies for tuberculosis patients. “Research fulfills my passion to discover unknown things about infectious disease and provides me with a valuable…

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Biosafety director earns acclaim for securing research pathogens

…. A lot of our human vaccines were developed in animals first. A lot of the equine vaccines for West Nile virus were tested and proven here, as were some of the new rabies vaccines for horses. Some of the newest vaccines for tuberculosis are being developed here. To do that, you need the resources from a lab standpoint and resources from a training standpoint to do it correctly and safely. Biosafety typically is concerned with pathogens that…

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International climate change experts converge on CSU Monday

…ng steel columns that blow carbon dioxide onto the foliage of trees and other plants to measure how they respond to elevated levels of a gas associated with climate change. For Orme, whose specialty is not climate change but tuberculosis research, seeing those towers and listening to HIE researchers was eye-opening. “You sit in a room with these people and you get the impression that we are in trouble,” said Orme, who wrote an opinion piece…

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Researcher: Fight malaria with deadly mosquito meals

…it one of the most difficult to treat infectious diseases globally. Of those who become ill, about 650,000 people die of malaria each year; most are children, and most are in Africa, according to the World Health Organization. CSU and the Gates Foundation Over the past decade, CSU has received 37 grants totaling about $14.5 million from the Bill and Melinda Gates Foundation for a variety of research projects, including studies targeting…

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Leprosy maintains stubborn hold through unexpected buddy system

…nsmitting the disease,” said Mary Jackson, a member of the research team and director of CSU’s Mycobacteria Research Laboratories. The labs are renowned for research to discover new diagnostics, therapies and preventions for tuberculosis and leprosy, diseases caused by mycobacterial pathogens that infect humans and animals. A new explanation for transmission The team’s discovery could help explain why the number of global leprosy cases hovers…

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Dry beans and rice bran: Can they prevent disease?

…focusing on how many dollars it’s going to take to do it,” Ryan said. “I feel pretty excited about the efficiency of my lab, the money we have received to do exciting work, and what we’ve been able to accomplish with it so far.” Read more: Prion studies yield insights into chronic wasting disease and human neurological illnesses Students compete with research into tuberculosis, heart disease, cancer, infertility, and more…

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